_Alfonso of ESTE ________________+
                                                         | (1526 - 1587)                   
                        _Cesare ESTE ____________________|
                       | (1562 - 1628) m 1585            |
                       |                                 |_Giulia of ROVERE _______________
                       |                                   (1531 - 1563)                   
 _Alfonso III of ESTE _|
| (1591 - 1644) m 1607 |
|                      |                                  _Cosimo I de' MEDICI ____________+
|                      |                                 | (1519 - 1574) m 1570            
|                      |_Virginia de' MEDICI ____________|
|                        (1568 - 1614) m 1585            |
|                                                        |_Camilla MARTELLI _______________
|                                                          (.... - 1590) m 1570            
|
|--Margherita of ESTE 
|  (1619 - 1692)
|                                                         _Emmanuel Philibert SAVOY _______+
|                                                        | (1528 - 1580) m 1684            
|                       _Charles Emmanuel SAVOY _________|
|                      | (1561 - 1630) m 1585            |
|                      |                                 |_Margaret of VALOIS-ANGOULÊME __+
|                      |                                   (1523 - 1574) m 1684            
|_Isabella of SAVOY ___|
  (1590 - 1626) m 1607 |
                       |                                  _Philip II HABSBURG _____________+
                       |                                 | (1527 - 1598) m 1559            
                       |_Catherine Michelle of HABSBURG _|
                         (1567 - 1597) m 1585            |
                                                         |_Elisabeth of VALOIS-ANGOULÊME _+
                                                           (1545 - 1568) m 1559