_Charles III of SAVOY ________+
                                                                    | (1486 - 1553) m 1521         
                                   _Emmanuel Philibert SAVOY _______|
                                  | (1528 - 1580) m 1684            |
                                  |                                 |_Beatrice of AVIZ ____________+
                                  |                                   (1504 - 1537) m 1521         
 _Charles Emmanuel SAVOY _________|
| (1561 - 1630) m 1585            |
|                                 |                                  _Francis I VALOIS-ANGOULÊME _+
|                                 |                                 | (1494 - 1547) m 1514         
|                                 |_Margaret of VALOIS-ANGOULÊME __|
|                                   (1523 - 1574) m 1684            |
|                                                                   |_Claude of VALOIS-ORLÉANS ___+
|                                                                     (1499 - 1524) m 1514         
|
|--Isabella of SAVOY 
|  (1590 - 1626)
|                                                                    _Charles V HABSBURG __________+
|                                                                   | (1499 - 1558) m 1526         
|                                  _Philip II HABSBURG _____________|
|                                 | (1527 - 1598) m 1559            |
|                                 |                                 |_Isabella of AVIZ ____________+
|                                 |                                   (1503 - 1539) m 1526         
|_Catherine Michelle of HABSBURG _|
  (1567 - 1597) m 1585            |
                                  |                                  _Henry II VALOIS-ANGOULÊME __+
                                  |                                 | (1519 - 1559)                
                                  |_Elisabeth of VALOIS-ANGOULÊME _|
                                    (1545 - 1568) m 1559            |
                                                                    |_Catherine de' MEDICI ________+
                                                                      (1519 - 1588)