_Philip of SAVOY __________+
                                            | (1490 - 1533) m 1528      
                       _Jacques of SAVOY ___|
                      | (1531 - 1585)       |
                      |                     |_Charlotte of ORLÉANS ____+
                      |                       (1512 - 1549) m 1528      
 _Henry I SAVOY ______|
| (1572 - 1632) m 1618|
|                     |                      _Ercole II ESTE ___________+
|                     |                     | (1508 - 1559)             
|                     |_Anna of ESTE _______|
|                       (1531 - 1607)       |
|                                           |_Renee of VALOIS-ORLÉANS _+
|                                             (1510 - 1574)             
|
|--Chalres Amadeus of SAVOY 
|  (1624 - 1652)
|                                            _Claude GUISE _____________+
|                                           | (1526 - 1572)             
|                      _Charles GUISE ______|
|                     | (1554 - 1631) m 1576|
|                     |                     |_Louise of BRÉZÉ ________
|                     |                       (.... - 1576)             
|_Anne of GUISE ______|
  (1600 - 1637) m 1618|
                      |                      _Rene GUISE _______________+
                      |                     | (1536 - 1566) m 1554      
                      |_Marie of GUISE _____|
                        (1555 - 1605) m 1576|
                                            |_Louise of RIEUX __________
                                              (1531 - 1570) m 1554