_Rene II LORRAINE _________+
                                                        | (1451 - 1508)             
                       _Claude LORRAINE ________________|
                      | (1496 - 1550) m 1513            |
                      |                                 |_Philippa of EGMOND _______+
                      |                                   (1462 - 1546)             
 _Rene GUISE _________|
| (1536 - 1566) m 1554|
|                     |                                  _Francis BOURBON-VENDÔME _+
|                     |                                 | (1470 - 1495)             
|                     |_Antoinette of BOURBON-VENDÔME _|
|                       (1494 - 1582) m 1513            |
|                                                       |_Marie of LUXEMBOURG ______+
|                                                         (1472 - 1547)             
|
|--Marie of GUISE 
|  (1555 - 1605)
|                                                        ___________________________
|                                                       |                           
|                      _________________________________|
|                     |                                 |
|                     |                                 |___________________________
|                     |                                                             
|_Louise of RIEUX ____|
  (1531 - 1570) m 1554|
                      |                                  ___________________________
                      |                                 |                           
                      |_________________________________|
                                                        |
                                                        |___________________________