_Rene II LORRAINE _________+
                                                        | (1451 - 1508)             
                       _Claude LORRAINE ________________|
                      | (1496 - 1550) m 1513            |
                      |                                 |_Philippa of EGMOND _______+
                      |                                   (1462 - 1546)             
 _Claude GUISE _______|
| (1526 - 1572)       |
|                     |                                  _Francis BOURBON-VENDÔME _+
|                     |                                 | (1470 - 1495)             
|                     |_Antoinette of BOURBON-VENDÔME _|
|                       (1494 - 1582) m 1513            |
|                                                       |_Marie of LUXEMBOURG ______+
|                                                         (1472 - 1547)             
|
|--Madeleine Diane of GUISE 
|  (1553 - ....)
|                                                        ___________________________
|                                                       |                           
|                      _________________________________|
|                     |                                 |
|                     |                                 |___________________________
|                     |                                                             
|_Louise of BRÉZÉ __|
  (.... - 1576)       |
                      |                                  ___________________________
                      |                                 |                           
                      |_________________________________|
                                                        |
                                                        |___________________________