_Francis I LORRAINE _________+
                                                        | (1517 - 1545) m 1541        
                          _Charles III LORRAINE ________|
                         | (1542 - 1608)                |
                         |                              |_Christina of OLDENBURG _____+
                         |                                (1521 - 1590) m 1541        
 _Henry II LORRAINE _____|
| (1563 - 1624)          |
|                        |                               _Henry II VALOIS-ANGOULÊME _+
|                        |                              | (1519 - 1559)               
|                        |_Claude of VALOIS-ANGOULÊME _|
|                          (1547 - 1574)                |
|                                                       |_Catherine de' MEDICI _______+
|                                                         (1519 - 1588)               
|
|--Nicole of LORRAINE 
|  (1608 - 1656)
|                                                        _Guglielmo GONZAGA __________+
|                                                       | (1538 - 1587)               
|                         _Vincenzo I GONZAGA __________|
|                        | (1562 - 1611)                |
|                        |                              |_Eleanor of HABSBURG ________+
|                        |                                (1534 - 1594)               
|_Margherita of GONZAGA _|
  (1591 - 1631)          |
                         |                               _Francesco I de' MEDICI _____+
                         |                              | (1541 - 1587)               
                         |_Eleanor de' MEDICI __________|
                           (1566 - 1611)                |
                                                        |_Joanna of HABSBURG _________+
                                                          (1546 - 1578)