_Rene II LORRAINE __________+ | (1451 - 1508) _Claude LORRAINE __________| | (1496 - 1550) m 1513 | | |_Philippa of EGMOND ________+ | (1462 - 1546) _Francis II GUISE ___| | (1518 - 1562) m 1548| | | _Francis BOURBON ___________+ | | | (1470 - 1495) | |_Antoinette of BOURBON ____| | (1494 - 1582) m 1513 | | |_Marie OF LUXEMBOURG _______ | (1472 - 1547) | |--Catherine-Marie of GUISE | (1551 - 1596) | ____________________________ | | | _Ercole II ESTE ___________| | | (1508 - 1559) | | | |____________________________ | | |_Anna of ESTE _______| (1531 - 1607) m 1548| | _Louis XII VALOIS-ORLÉANS _+ | | (1462 - 1514) m 1499 |_Renee of VALOIS-ORLÉANS _| (1510 - 1574) | |_Anne of DREUX-MONTFORT ____+ (1476 - 1513) m 1499