_Ludovico de' MEDICI ______+
                                                  | (1498 - 1526)             
                           _Cosimo I de' MEDICI __|
                          | (1519 - 1574)         |
                          |                       |_Maria SALVIATI ___________+
                          |                         (1499 - 1543)             
 _Francesco I de' MEDICI _|
| (1541 - 1587)           |
|                         |                        _Pedro Alvarez ALBA _______+
|                         |                       | (1484 - 1552) m 1508      
|                         |_Eleanor Alvarez ALBA _|
|                           (1521 - 1562)         |
|                                                 |_Maria OSORIO-Y-PIMENTEL __
|                                                    m 1508                   
|
|--Isabella de' MEDICI 
|  (1571 - 1572)
|                                                  _Philip I HABSBURG ________+
|                                                 | (1478 - 1506)             
|                          _Ferdinand I HABSBURG _|
|                         | (1502 - 1564)         |
|                         |                       |_Joanna I of TRASTÁMARA __+
|                         |                         (1479 - 1555)             
|_Joanna of HABSBURG _____|
  (1546 - 1578)           |
                          |                        _Vladislaus II JAGIEŁŁO _+
                          |                       | (1455 - 1515) m 1502      
                          |_Anne of JAGIEŁŁO ___|
                            (1503 - 1546)         |
                                                  |_Anne of FOIX-CANDALE _____+
                                                    (1484 - 1506) m 1502