_Claude LORRAINE ________________+
                                                | (1496 - 1550) m 1513            
                           _Francis II GUISE ___|
                          | (1518 - 1562) m 1548|
                          |                     |_Antoinette of BOURBON-VENDÔME _+
                          |                       (1494 - 1582) m 1513            
 _Louis II GUISE _________|
| (1555 - 1588)           |
|                         |                      _Ercole II ESTE _________________+
|                         |                     | (1508 - 1559)                   
|                         |_Anna of ESTE _______|
|                           (1531 - 1607) m 1548|
|                                               |_Renee of VALOIS-ORLÉANS _______+
|                                                 (1510 - 1574)                   
|
|--Louis GUISE 
|  (1588 - 1631)
|                                                _________________________________
|                                               |                                 
|                          _____________________|
|                         |                     |
|                         |                     |_________________________________
|                         |                                                       
|_Aimerie of LESCHERAINE _|
                          |
                          |                      _________________________________
                          |                     |                                 
                          |_____________________|
                                                |
                                                |_________________________________