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Father: Francis II GUISE #73507
Mother: Anna of ESTE #87224
_Rene II LORRAINE __________+
| (1451 - 1508)
_Claude LORRAINE ________________|
| (1496 - 1550) m 1513 |
| |_Philippa of EGMOND ________+
| (1462 - 1546)
_Francis II GUISE ___|
| (1518 - 1562) m 1548|
| | _Francis BOURBON-VENDÔME __+
| | | (1470 - 1495)
| |_Antoinette of BOURBON-VENDÔME _|
| (1494 - 1582) m 1513 |
| |_Marie of LUXEMBOURG _______+
| (1472 - 1547)
|
|--François GUISE
| (1559 - 1573)
| _Alfonso I of ESTE _________+
| | (1476 - 1534)
| _Ercole II ESTE _________________|
| | (1508 - 1559) |
| | |_Lucrezia BORGIA ___________+
| | (1480 - 1519)
|_Anna of ESTE _______|
(1531 - 1607) m 1548|
| _Louis XII VALOIS-ORLÉANS _+
| | (1462 - 1514) m 1499
|_Renee of VALOIS-ORLÉANS _______|
(1510 - 1574) |
|_Anne of DREUX-MONTFORT ____+
(1476 - 1513) m 1499