_Rene II LORRAINE __________+
                                                        | (1451 - 1508)              
                       _Claude LORRAINE ________________|
                      | (1496 - 1550) m 1513            |
                      |                                 |_Philippa of EGMOND ________+
                      |                                   (1462 - 1546)              
 _Francis II GUISE ___|
| (1518 - 1562) m 1548|
|                     |                                  _Francis BOURBON-VENDÔME __+
|                     |                                 | (1470 - 1495)              
|                     |_Antoinette of BOURBON-VENDÔME _|
|                       (1494 - 1582) m 1513            |
|                                                       |_Marie of LUXEMBOURG _______+
|                                                         (1472 - 1547)              
|
|--Charles GUISE 
|  (1554 - 1611)
|                                                        _Alfonso I of ESTE _________+
|                                                       | (1476 - 1534)              
|                      _Ercole II ESTE _________________|
|                     | (1508 - 1559)                   |
|                     |                                 |_Lucrezia BORGIA ___________+
|                     |                                   (1480 - 1519)              
|_Anna of ESTE _______|
  (1531 - 1607) m 1548|
                      |                                  _Louis XII VALOIS-ORLÉANS _+
                      |                                 | (1462 - 1514) m 1499       
                      |_Renee of VALOIS-ORLÉANS _______|
                        (1510 - 1574)                   |
                                                        |_Anne of DREUX-MONTFORT ____+
                                                          (1476 - 1513) m 1499