_Claude LORRAINE __________________+
                                                   | (1496 - 1550) m 1513              
                       _Francis II GUISE __________|
                      | (1518 - 1562) m 1548       |
                      |                            |_Antoinette of BOURBON-VENDÔME ___+
                      |                              (1494 - 1582) m 1513              
 _Charles GUISE ______|
| (1554 - 1611) m 1576|
|                     |                             _Ercole II ESTE ___________________+
|                     |                            | (1508 - 1559)                     
|                     |_Anna of ESTE ______________|
|                       (1531 - 1607) m 1548       |
|                                                  |_Renee of VALOIS-ORLÉANS _________+
|                                                    (1510 - 1574)                     
|
|--Charles Emanuel GUISE 
|  (1581 - 1609)
|                                                   _René of SAVOY ___________________+
|                                                  | (1473 - 1525) m 1500              
|                      _Honorat II of SAVOY _______|
|                     | (1511 - 1580) m 1540       |
|                     |                            |_Anne LASCARIS ____________________
|                     |                               m 1500                           
|_Henriette of SAVOY _|
  (.... - 1611) m 1576|
                      |                             _Alain of FOIX ____________________+
                      |                            |                                   
                      |_Jeanne Françoise of FOIX _|
                        (.... - 1542) m 1540       |
                                                   |_Françoise of Montpezat DES PREZ _